The tuition cost is around 29,000 USD.

On-campus and off-campus residence living is offered for students. Towers East and Towers South Residence Halls (4530 USD) + Classic Meal Plan (2780 USD). Southeast Missouri State University's Board of Regents requires all full-time students to live on campus for two academic years. For their students, the university includes ten living halls and ten eating facilities. Towers East, Towers North, Towers West, Towers South, Vandiver, and LaFerla are among the residence halls on the list. Off-campus accommodation costs roughly 1000 to 1500 USD per month on average.

There were 8,929 undergraduates and 1,072 graduate students enrolled. With over 475 international students, the student population represents 50 states and 55 countries from around the world. Southeast Missouri State University admissions are competitive, with a 93 percent acceptance rate.

Southeast Missouri State University is spread across 400 acres of land in Cape Girardeau, Missouri, the largest city between St. Louis and Memphis. The institution has three Missouri campuses: Springfield, West Plaines, and Mountain Grove. Aside from that, the college has a satellite campus in Dalian, China. Springfield is Missouri State University's main campus, spanning more than 225 acres. Over 238 student organisations are available at the university, and more than 40% of undergraduate students are involved in at least one of them. Southeast participates in NCAA Division I, Ohio Valley Conference athletics, with nearly 5,000 students involved in intramural sports or sports clubs.

The University as a whole is accredited through the Higher Learning Commission's Commission on Institutions of Higher Education.

The university includes a Career Development Center that assists students with career and internship opportunities. REDHAWKjobs.com is the university's online recruiting system, which handles job and internship placements and provides a platform for both employers and students. The university also teaches students how to write resumes and prepares them for job interviews. The institution also hosts physical and virtual career fairs. With a graduation rate of 50%, 93 percent of graduates find work within two years after graduation, earning a median wage of 37,000 USD per year, compared to the national average of 33,028 USD.